WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:PPAR signaling pathway       ID:03320
C=70; O=7; E=0.21; R=33.17; rawP=1.97e-09; adjP=6.30e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000099194 NA SCD stearoyl-CoA desaturase (delta-9-desaturase) 6319 ENSG00000099194
2  ENSG00000109424 NA UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 7350 ENSG00000109424
3  ENSG00000132170 NA PPARG peroxisome proliferator-activated receptor gamma 5468 ENSG00000132170
4  ENSG00000181092 NA ADIPOQ adiponectin, C1Q and collagen domain containing 9370 ENSG00000181092
5  ENSG00000166819 NA PLIN1 perilipin 1 5346 ENSG00000166819
6  ENSG00000170323 NA FABP4 fatty acid binding protein 4, adipocyte 2167 ENSG00000170323
7  ENSG00000124253 NA PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 5105 ENSG00000124253


Database:KEGG pathway       Name:Glycerolipid metabolism       ID:00561
C=50; O=5; E=0.15; R=33.17; rawP=4.38e-07; adjP=7.01e-06
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000119927 NA GPAM glycerol-3-phosphate acyltransferase, mitochondrial 57678 ENSG00000119927
2  ENSG00000169692 NA AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) 10555 ENSG00000169692
3  ENSG00000058866 NA DGKG diacylglycerol kinase, gamma 90kDa 1608 ENSG00000058866
4  ENSG00000168237 NA GLYCTK glycerate kinase 132158 ENSG00000168237
5  ENSG00000062282 NA DGAT2 diacylglycerol O-acyltransferase 2 84649 ENSG00000062282


Database:KEGG pathway       Name:Neuroactive ligand-receptor interaction       ID:04080
C=272; O=7; E=0.82; R=8.54; rawP=2.01e-05; adjP=0.0002
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000152822 NA GRM1 glutamate receptor, metabotropic 1 2911 ENSG00000152822
2  ENSG00000174697 NA LEP leptin 3952 ENSG00000174697
3  ENSG00000065325 NA GLP2R glucagon-like peptide 2 receptor 9340 ENSG00000065325
4  ENSG00000050628 NA PTGER3 prostaglandin E receptor 3 (subtype EP3) 5733 ENSG00000050628
5  ENSG00000144891 NA AGTR1 angiotensin II receptor, type 1 185 ENSG00000144891
6  ENSG00000168398 NA BDKRB2 bradykinin receptor B2 624 ENSG00000168398
7  ENSG00000118432 NA CNR1 cannabinoid receptor 1 (brain) 1268 ENSG00000118432


Database:KEGG pathway       Name:Insulin signaling pathway       ID:04910
C=138; O=5; E=0.42; R=12.02; rawP=6.48e-05; adjP=0.0004
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000142949 NA PTPRF protein tyrosine phosphatase, receptor type, F 5792 ENSG00000142949
2  ENSG00000177885 NA GRB2 growth factor receptor-bound protein 2 2885 ENSG00000177885
3  ENSG00000079435 NA LIPE lipase, hormone-sensitive 3991 ENSG00000079435
4  ENSG00000169710 NA FASN fatty acid synthase 2194 ENSG00000169710
5  ENSG00000124253 NA PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 5105 ENSG00000124253


Database:KEGG pathway       Name:Complement and coagulation cascades       ID:04610
C=69; O=4; E=0.21; R=19.23; rawP=5.85e-05; adjP=0.0004
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000188488 NA SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 5104 ENSG00000188488
2  ENSG00000125730 NA C3 complement component 3 718 ENSG00000125730
3  ENSG00000127241 NA MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 5648 ENSG00000127241
4  ENSG00000168398 NA BDKRB2 bradykinin receptor B2 624 ENSG00000168398


Database:KEGG pathway       Name:Glycerophospholipid metabolism       ID:00564
C=80; O=4; E=0.24; R=16.59; rawP=0.0001; adjP=0.0005
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000119927 NA GPAM glycerol-3-phosphate acyltransferase, mitochondrial 57678 ENSG00000119927
2  ENSG00000169692 NA AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) 10555 ENSG00000169692
3  ENSG00000058866 NA DGKG diacylglycerol kinase, gamma 90kDa 1608 ENSG00000058866
4  ENSG00000167588 NA GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2819 ENSG00000167588


Database:KEGG pathway       Name:Calcium signaling pathway       ID:04020
C=177; O=5; E=0.53; R=9.37; rawP=0.0002; adjP=0.0009
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000152822 NA GRM1 glutamate receptor, metabotropic 1 2911 ENSG00000152822
2  ENSG00000050628 NA PTGER3 prostaglandin E receptor 3 (subtype EP3) 5733 ENSG00000050628
3  ENSG00000144891 NA AGTR1 angiotensin II receptor, type 1 185 ENSG00000144891
4  ENSG00000123360 NA PDE1B phosphodiesterase 1B, calmodulin-dependent 5153 ENSG00000123360
5  ENSG00000168398 NA BDKRB2 bradykinin receptor B2 624 ENSG00000168398


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=11; E=3.41; R=3.23; rawP=0.0006; adjP=0.0024
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000237289 NA CKMT1B creatine kinase, mitochondrial 1B 1159 ENSG00000237289
2  ENSG00000169692 NA AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) 10555 ENSG00000169692
3  ENSG00000173599 NA PC pyruvate carboxylase 5091 ENSG00000173599
4  ENSG00000062282 NA DGAT2 diacylglycerol O-acyltransferase 2 84649 ENSG00000062282
5  ENSG00000169710 NA FASN fatty acid synthase 2194 ENSG00000169710
6  ENSG00000124253 NA PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 5105 ENSG00000124253
7  ENSG00000119927 NA GPAM glycerol-3-phosphate acyltransferase, mitochondrial 57678 ENSG00000119927
8  ENSG00000092621 NA PHGDH phosphoglycerate dehydrogenase 26227 ENSG00000092621
9  ENSG00000058866 NA DGKG diacylglycerol kinase, gamma 90kDa 1608 ENSG00000058866
10  ENSG00000168237 NA GLYCTK glycerate kinase 132158 ENSG00000168237
11  ENSG00000142657 NA PGD phosphogluconate dehydrogenase 5226 ENSG00000142657


Database:KEGG pathway       Name:Adipocytokine signaling pathway       ID:04920
C=68; O=3; E=0.20; R=14.64; rawP=0.0012; adjP=0.0043
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000174697 NA LEP leptin 3952 ENSG00000174697
2  ENSG00000181092 NA ADIPOQ adiponectin, C1Q and collagen domain containing 9370 ENSG00000181092
3  ENSG00000124253 NA PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 5105 ENSG00000124253


Database:KEGG pathway       Name:Biosynthesis of unsaturated fatty acids       ID:01040
C=21; O=2; E=0.06; R=31.59; rawP=0.0018; adjP=0.0058
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000099194 NA SCD stearoyl-CoA desaturase (delta-9-desaturase) 6319 ENSG00000099194
2  ENSG00000206527 NA PTPLB protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b 201562 ENSG00000206527




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).